How Do TB Drugs Interact With HIV Drugs?
How do TB drugs interact with HIV drugs? – In January, 2012, the US Food and Drug Administration (FDA) issued new guidelines on dosing of an HIV medication used to treat people infected with both HIV and tuberculosis (TB) because of a potential interaction between two of the main drugs used to treat each disease. The drug rifampin, used for treating TB, can lower levels of the HIV medicine efavirenz, so the FDA recommended that patients who weigh more than 50 kg (110 pounds) and who are taking both medications should get 30 percent larger doses of efavirenz (an increase from 600 mg to 800 mg). Now, a new analysis by conducted by researchers with the Adult AIDS Clinical Trials Group (ACTG) at the University of California, San Francisco (UCSF) and the San Francisco General Hospital and Trauma Center (SFGH) suggests this recommended dose adjustment may not be necessary, particularly in non-Caucasian populations. As described in a talk at the XIX International AIDS Conference in Washington, DC on Monday, July 23, 2012, the new FDA guidelines were based on several small studies in European TB patients and one in healthy volunteers, indicating a decrease in efavirenz levels with rifampin. The guidelines were also informed by a mathematical model, which showed that increasing efavirenz to 800 mg when given with rifampin would increase levels to those seen on the regular dose of 600 mg. These data may not apply to patients in African and Asian populations because of genetic differences that lead to higher efavirenz levels …
HUFFPOST HILL, sponsored by the American Petroleum Institute – Sarah Palin …
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Laura Bassett: "As hundreds of thousands of people braved sub-freezing temperatures in Washington, D.C., on Friday to join the anti-abortion protest March for Life, House Speaker John Boehner (R-Ohio) took the opportunity to reiterate his commitment to …
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Trent Williams Reportedly Pulled out of Pro Bowl Following Altercation
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Washington Redskins left tackle Trent Williams was reportedly involved in an altercation on Thursday night that left him with a wound requiring stitches. He will miss the 2013 Pro Bowl as a result, according to Grant Paulsen of 106.7 THE FAN in …
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Oxytrol Approved for Women to Treat Overactive Bladder
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Washington, D.C. – infoZine – The U.S. Food and Drug Administration approved Oxytrol for Women, the first over-the-counter treatment for overactive bladder in women ages 18 years and older. Oxytrol will remain available for men with overactive bladder …
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